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KMID : 0360319970290020257
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Journal of Korean Cancer Research Association
1997 Volume.29 No. 2 p.257 ~ p.265
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Quantitative Correlation between the Biochemical Markers and the Extent of Metastatic Bone Tumors
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김수경
조덕수/백현선/김세화/김민철/신성혜/이영희/박주흥
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Abstract
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Purpose:
@EN We investigated the usefulness of urinary pyridinoline(uPyr) and deoxypyridinoline(uDpyr) and serum osteocalcin as markers of bone metastasis, particularly focussing on quantitative correlation between the degree of bone metastasis and the
level of
biochemical markers.
@ES Materials and Methods:
@EN By using ELISA method we measured the level of uPyr, uDpyT. And osteocalcin in 100 cancer patients of whom 58 patients had bone metastasis, 42 had no bone metastasis, and 44 control subjects.
@ES Results:
@EN There was a significant difference in uPyr level between the patients with bone metastasis and the patients without bone metastasis or control group (mean±SD, 70.26±43.11 vs 38.93±21.48 or 25.13±8.81 nM/mM Creatinine, p<0.05). And uDpyr
level
showed more significant elevation in the patients with bone metastasis than in the patients without bone metastasis and in control group (12.63±7.51 vs 6.44±3.58 and 4.23±1.70 nM/mM Creatinine p<0.05). Osteocalcin level showed no significant
difference among groups. We could demonstrate a significant quantitative correlation between the extent of bone metastasis and the amount of uPyr (r=0.7482, p<0.001) or uDpyr (r=0.5992, p<0.001).
@ES Conclusion:
@EN uPyr and uDpyr were significantly increased in metastatic bone tumors and quantitatively correlated well with the extent of bone metastasis. Therefore we can use these two markers as an evidence of bone metastasis. Further studies are
recommended to
decide the usefulness of these markers in the early detection of bone metastasis and in the assessment of response to antiresorptive treatments.
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KEYWORD
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